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This drug and its metabolites are known to be substantially excreted by the kidney, and the risk of toxic reactions might be greater in patients with impaired renal function [see Clinical Pharmacology (12. It leads to estrogen and progesterone levels similar to those of the early follicular phase. If excessive bleeding or oozing occurs, you should contact our office apotheke-rezeptfreie.com. Some people, especially pregnant women, should not take methotrexate.